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Tissue-resident immune cells play key roles in organ physiology by their cross-talk with non-immune cells. Following their distribution within developing organs during a perinatal window or later during life, these resident immune cells acquire tissue-specific gene expression signatures and are primed for rapid local responses. Our lab has a strong interest in type 2 immune pathways, including ILC2s and epithelial tuft cells, and we explore the molecular mechanisms, which mediate critical sentinel function in detection of tissue perturbation, regulation of remodeling, and adaptation to dynamically changing environments.
To achieve these aims, we combine mouse models, in vitro organoid systems, and advanced analysis techniques.
Our laboratory is located on the UZH Irchel Campus, Building Y23, J-Floor.