PhD Position in Endolysosome Biology and Kidney Epithelial Diseases
Description of research group
Our group is investigating mechanisms of kidney diseases, a growing health issue in Switzerland. Our translational studies are using molecular and cell biology techniques, metabolic studies and genetics applied on mouse models. We play an active role in international consortia (EURenOmics, TranCYST) and collaborative networks in Switzerland. Ultimately, our goal is to improve the understanding and the treatment of diseases affecting the kidney.
A PhD position is currently available in a dynamic, international research group investigating endolysosomal disorders primarily affecting the kidney.
- The endolysosomal system sustains the reabsorptive activity of specialized epithelial cells, hence their role in homeostasis.
- In view of their crucial role in reabsorbing and processing essential nutrients, the proximal tubule epithelial cells provide a particularly well–suited model to investigate pathogenic mechanisms underlying epithelial cell disorders.
- Based on a translational approach using cell–and–animal based models combined with advanced live cell microscopy and in vitro biochemical assays, we are investigating the links between dysregulation of endolysosomal system, defective epithelial function and progression of kidney disease.
- The current project will address: (i) how the endolysosome system maintains the epithelial cell differentiation and function; (ii) how these mechanisms are altered in rare and common kidney diseases; and (iii) how drug discovery strategies can rescue the cellular phenotype.
- These studies will use available cell and transgenic mouse and zebrafish models, with access to technological platforms (phenotyping, imaging, cell physiology, and functional genomics) and to patient material (European networks, biobanks, and GWAS cohorts). Our group is particularly involved in national (ZIHP and Radiz) and European (EUNEFRON; EURenOmics; ERA-EDTA) and international (Cystinosis Research Foundation, CRF) networks on rare genetic diseases.
Very good spoken and written English is essential. Additional German or French is a useful surplus.
Profile: We are looking for recent graduates (Master of Science in biology or pharmaceutical sciences or similar) who are strongly interested in cell biology and/or in disease–oriented research, and who are enthusiastic and with a drive scientific innovation and discovery.
Excellent living conditions and attractive salary in Switzerland; first-class research environment, focused on a translational research with high medical relevance; multiple interactions and international environment within the University and Academic Hospital in Zurich; networking and recognition in the field of rare diseases.
This position opens on: As soon as possible
Please send a single PDF file with CV, bibliography, motivation towards the position (that could include a brief statement of own career objectives), and a list of 3 potential referees to: email@example.com