Hiking at high altitude, performing sports at the limits, suffering from cancer or vascular disease (stroke, infarction, thrombosis) - what each of these things has in common is an insufficient oxygen supply of the tissues of our body.
Our group explores the molecular mechanisms and therapeutical consequences of cellular sensing, signalling and adaptation to changing oxygen availability.
- We search for and characterize novel proteins regulated via proline and asparagine hydroxylation by the oxygen-sensing PHD and FIH family of enzymes.
- We try to understand the differences between hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha and their corresponding target genes.
- We investigate the oxygen/FIH-dependent function of the deubiquitinase OTUB1.
- We develop novel transgenic mouse lines to study renal erythropoietin-producing (REP) cells in vivo and in vitro.
To achieve these aims, we use the latest techniques of life science research, including biochemical, immunological, molecular and cell biological techniques as well as genetically modified cells and animals.