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Research Projects

Physiology of transport mechanisms:

  • Mechanisms and regulation of endocytosis in the proximal tubule
  • Salt and water handling by distal nephron segments
  • Ontogeny and transcriptional regulation of transport systems
  • Mechanisms of differentiation of epithelial cells
  • Genome-wide association studies for renal function parameters

Pathophysiology of inherited kidney disorders:

  • Mechanisms and consequences of proteinuria
  • Pathophysiology of inherited forms of chronic interstitial nephritis, including uromodulin-associated kidney disorders
  • Gitelman syndrome and salt-losing tubulopathies
  • Clinical and genetic aspects of polycystic kidney and liver diseases
  • Characterization of mouse models generated by random mutagenesis (ENU)
  • Characterization of urinary biomarkers for tubular disorders

Mechanisms of water and solute transport across the peritoneal membrane:

  • Improving the efficiency of water and solute removal during peritoneal dialysis
  • Role and regulation of water channels in endothelial cells
  • Development of mouse models of peritoneal dialysis
  • Mechanisms of osmosis, characterization of alternate osmotic agents
  • Genetic influence on transport parameters

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