Epithelial Cancers
Most relevant publications of the last few years:
Research articles
Thoma CR, Toso A, Gutbrodt KL, Reggi SP, Frew IJ, Schraml P, Hergovich A, Moch H, Meraldi P, Krek W.(2009).
VHL loss causes spindle mis-orientation and chromosome instability.
Nat Cell Biol. 11: 994-1001
Schraml P, Frew IJ, Thoma CR, Boysen G, Struckmann K, Krek W and Moch H (2009).
Sporadic clear cell renal cell carcinoma but not the papillary type is characterized by severely
reduced frequency of primary cilia.
Mod Pathol. 22: 31-6
Frew IJ, Thoma CR, Georgiev S, Minola A, Hitz M, Montani M, Moch H and Krek W (2008).
pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation.
EMBO J. 27: 1747-57
Frew IJ, Minola A, Georgiev S, Hitz M, Moch H, Richard S, Vortmeyer AO and Krek W (2008).
Combined Vhlh and Pten mutation causes genital tract cystadenoma and squamous metaplasia.
Mol Cell Biol. 28: 4536-48
Thoma CR*, Frew IJ*, Hoerner CR, Montani M, Moch H, and Krek W (2007).
pVHL and GSK3ß are components of a primary cilium-maintenance signalling network.
Nat Cell Biol. 9: 588-95. * joint first authors
Frew IJ*, Sims NA*, Quinn JM, Walkley CR, Purton LE, Bowtell DDL and MT Gillespie (2004).
Osteopenia in Siah1a mutant mice.
J Biol Chem. 279: 29583-8. * joint first authors
Nakayama K, Frew IJ, Hagensen M, Skals M, Habelhah H, Bhoumik A, Kadoya T, Erdjument-Bromage H, Tempst P, Frappell PB, Bowtell DDL and Z Ronai (2004).
Siah2 regulates stability of prolyl-hydroxylases, controls HIF1α abundance,
and modulates physiological responses to hypoxia.
Cell. 117: 941-52
Frew IJ, Hammond VE, Dickins RA, Quinn JM, Walkley CR, Sims NA, Schnall R, Della NG, Holloway AJ, Digby MR, Janes PW, Tarlinton DM, Purton LE, Gillespie MT, and DDL Bowtell (2003).
Generation and analysis of Siah2 mutant mice.
Mol Cell Biol. 23: 9150-61
House CM, Frew IJ, Huang HL, Wiche G, Traficante N, Nice E, Catimel B and DDL Bowtell (2003).
A binding motif for Siah ubiquitin ligase.
Proc Natl Acad Sci USA. 100: 3101-6
Frew IJ, Dickins RA, Cuddihy AR, Del Rosario M, Reinhard C, O’Connell MJ and DDL Bowtell (2002).
Normal p53 function in primary cells deficient for Siah genes.
Mol Cell Biol. 22: 8155-64
Habelhah H, Frew IJ, Laine A, Janes PW, Relaix F, Sassoon D, Bowtell DDL and Z Ronai (2002).
Stress-induced decrease in TRAF2 stability is mediated by Siah2.
EMBO J. 21: 5756-65
Dickins RA, Frew IJ, House CM, O’Bryan M, Holloway AJ, Haviv I, Traficante N, de Kretser D, Ashley T and DDL Bowtell (2002)
The ubiquitin ligase component Siah1a is required for completion of meiosis I in male mice.
Mol Cell Biol. 22: 2294-2303
Berven LA, Frew IJ and MF Crouch (1999).
Nitric oxide donors selectively potentiate thrombin-stimulated p70(S6k) activity
and morphological changes in Swiss 3T3 cells.
Biochem Biophys Res Commun. 266: 352-60
Review articles
Frew IJ and Krek W (2008).
pVHL: a multipurpose adaptor protein.
Science Signaling. 1(24): pe30
Frew IJ and Krek W (2007).
Multitasking by pVHL in tumour suppression.
Current Opinion in Cell Biology. 19: 685-90
Thoma CR*, Frew IJ* and Krek W (2007).
The VHL tumour suppressor: riding tandem with GSK3β in primary cilium-maintenance.
Cell Cycle. 6: 1809-13. * joint first authors
For more use MedLine in the Link section.