Epithelial Transport
The overall theme of our research is solute transport across membranes, in particular across epithelial barriers, and its role in maintaining the constancy of the 'milieu intérieur', i.e. body homeostasis.
Our current general aims are
- understanding mechanisms and roles of amino acid transport
- elucidating mechanisms by which aldosterone regulates sodium reabsorption
- understanding the mechanism of antibiotic pumping by bacterial AcrB
- investigating the biophysics of phosphate transport
A most exciting dimension of our research activity on these “boundary functions” is the fact that we address and try to integrate questions at all levels, from gene regulation and protein structure via cellular mechanisms to tissue and systemic organisation and function.
Our focus on specific functions, combined with a breadth of approaches at different levels of complexity, is the hallmark of the experimental integrative physiology we are performing.