Cell Physiology and Glycobiology

Most relevant publications of the last few years


Roblek M., Strutzmann E., Zankl C., Adage T., Heikenwalder M., Atlic A., Weis R., Kungl A., Borsig L.
Targeting of CCL2-CCR2 Axis Using CCL2 Decoy Protein Attenuates Metastasis by Inhibition of Tumor Cell Seeding.
Neoplasia 18:49-59 (2016)


Häuselmann I., Roblek M., Protsyuk D., Huck V., Knopfova L., Grässle S., Bauer A.T., Schneider SW., Borsig L.
E-selectin-mediated activation of monocytes and pulmonary endothelia induce vascular permeability and promote metastasis in mice.
Cancer Res 76:5302-12 (2016)


Müller-Edenborn K., Legér K., Glaus Garzon J., Oertli C., Mirsaidi A., Richards, P.J., Rehrauer H., Spielmann P., Hoogewijs D., Borsig L., Hottiger M.O., Wenger R.H.
Hypoxia attenuates the inflammatory response in colon cancer cells by regulating IkB
Oncotarget 6:20288-301 (2015)


Nowicka A.M., Häuselmann I., Borsig L., Bolduan S., Schindler M., Schraml P., Heikenwälder M., Holger Moch M.
NEMO-driven pVHL-independent activation of HIF induces clear cell renal cell carcinoma progression.
Oncogene 2015 Oct 26. doi: 10.1038/onc.2015.400 (2015)


Roblek M., Calin M., Schlesinger M., Stan D., Zeisig R., Simionescu M., Bendas G., Borsig L.
Targeted delivery of CCR2 antagonist to activated pulmonary endothelium prevents metastasis.
J Control Release 220 (Pt A):341-347 (2015)


Hoos A., Protsyuk D., Borsig L.
Metastatic growth progression caused by PSGL-1-mediated recruitment of monocytes to metastatic sites.
Cancer Res 74(3):695-704 (2014)

Kurakevich, E., Hennet, T., Hausmann, M., Rogler, G., Borsig L.
Milk oligosaccharide sialyl(α2,3)lactose activates intestinal CD11c+ cells through TLR4.
Proc. Natl. Acad. Sci. USA 110(43):17444-9 (2013)

Wolf M.J., Hoos A., Bauer J., Boettcher S., Knust M., Weber A., Simonavicius N., Moch H., Manz M., Stürzl M., Croner R.S., Konrad A., Schneider C., Aguzzi A., van Loo G., Pasparakis M., Prinz M., Mathias Heikenwälder M., Borsig L.
Endothelial CCR2 signaling induced by colon carcinoma cells licenses extravasation via the JAK2-Stat5 and p38MAPK pathway.
Cancer Cell 22(19):91-105 (2012)



Hennet, T., Borsig L.
Breastfed at Tiffany’s
Trends Biochem Sci. 41:508-18 (2016)

O’Connor T., Borsig L., Heikenwalder M.
CCL2-CCR2 signaling in disease pathogenesis.
Endocr Metab Immune Disord Drug Targets 15(2):105-18 (2015)


Borsig L., Wolf M.J., Roblek, M., Lorentzen, A., Heikenwälder M.
Inflammatory chemokines and metastasis – tracing the accessory.
Oncogene 33(25):3217-24 (2014)

Häuselmann I., Borsig L.
Altered tumor cell glycosylation promotes metastasis.
Front Oncol 4:28 (2014)

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