Research Projects
Main Research Topics of the Interface Group:
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A paradigm that has emerged over several decades from diverse fields of cancer research is that uncontrolled cellular proliferation and tumour initiation in most epithelial cell types results not from the mutation of single genes, but rather involves the dysregulation of multiple tumour suppressor and/or oncogenic pathways that act in a cooperative manner to induce proliferation. Major current themes of our research centre around unraveling the potential cooperative roles of oxygen-regulated signaling pathways (VHL tumour suppressor protein and HIFα transcription factors), cell cycle regulatory networks, Wnt- β-catenin signaling and signaling by the primary cilium in kidney and endometrial tumours.