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Kayhan M., Vouillamoz J., Gonzalez Rodriguez D., Bugarski M., Mitamura Y., Gschwend J., Schneider C., Hall A., Legouis D., Akdis C., Peter L., Rehrauer H., Gewin L., Wenger R.H., Nlandu Khodo S.
Intrinsic TGF-β 1 signaling attenuates proximal tubule mitochondrial injury and inflammation in chronic kidney disease.
Nat. Commun. 2023, 14(1):3236
Kragesteen B.K., Giladi A., David E., Halevi S., Geirsdóttir L., Lempke O.M., Li B., Bapst A.M., Xie K., Katzenelenbogen Y., Dahl S.L., Sheban F., Gurevich-Shapiro A., Zada M., San Phan T., Avellino R., Wang S.-Y., Barboy O., Shlomi S., Winning S., Markwerth P.P., Dekalo S., Keren-Shaul H., Kedmi M., Sikora M., Fandrey J., Korneliussen T., Prchal J.T., Rosenzweig B., Yutkin V., Racimo F.*, Willerslev E., Gur C., Wenger R.H., Amit I.
The transcriptional and regulatory identity of erythropoietin producing cells.
Nat. Med. 2023, 1191-1200
Keppner A., Correia M., Santambrogio S., Koay T.W., Maric D., Osterhof C., Winter D.V., Clerc A., Stumpe M., Chalmel F., Dewilde S., Odermatt A., Kressler D., Hankeln T., Wenger R.H., Hoogewijs D.
Androglobin, a chimeric mammalian globin, is required for male fertility.
eLife 2022,14, 11, e72374
Bapst A.M., Knöpfel T., Nolan K.A., Imeri F., Schuh C.D., Hall A.M., Katschinski D.M., Wenger R.H.
Neurogenic and pericytic plasticity of conditionally immortalized cells derived from renal erythropoietin-producing cells.
J. Cell. Physiol. 2022, 237, 2420-2433
Ruiz-Serrano A., Boyle C.N., Monné Rodríguez J.M., Günter J., Jucht A.E., Pfundstein S., Bapst A.M., Lutz T.A., Wenger R.H., Scholz C.C.
The deubiquitinase OTUB1 is a key regulator of energy metabolism.
Int. J. Mol. Sci. 2022, 23, 1536, 1-15
Dahl S.L., Pfundstein S., Hunkeler R., Dong X., Knöpfel T., Spielmann P., Scholz C.C., Nolan K.A., Wenger R.H.
Fate and therapeutic recruitment of spatially defined Epo-producing cells in mouse models of hypoxia and renal anemia.
Acta Physiol. (Oxf.) 2022, 234, e13768
Corre T., Ponte B., Pivin E., Pruijm M., Ackermann D., Ehret G., Spanaus K., Bochud M., Wenger R.H.
Heritability and association with distinct genetic loci of erythropoietin levels in the general population.
Haematologica 2021, 106, 2499-2501
Ruiz-Serrano A., Monné Rodríguez J.M., Günter J., Sherman S.P.M., Jucht A.E., Fluechter P., Volkova Y.L., Pfundstein S., Pellegrini G., Wagner C.A., Schneider C., Wenger R.H., Scholz C.C.
OTUB1 regulates lung development, adult lung tissue homeostasis and respiratory control.
FASEB J. 2021, 35, e22039, 1-16
Orlando I.M.C., Lafleur V.N., Storti F., Spielmann P., Crowther L., Santambrogio S., Schödel J., Hoogewijs D., Mole D.R., Wenger R.H.
Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression
Haematologica 2020,105, 2774-2784
Randi E.B., Benjamin V., Tsachaki M., Porto E., Vermeylen S., Lindenmeyer M.T., Le T.T.T., Cohen C.D., Devuyst O., Kistler A., Szabo C., Kawada N., Hankeln T., Odermatt A., Dewilde S., Wenger R.H., Hoogewijs D.
The anti-oxidative role of cytoglobin in podocytes suggests an association with chronic kidney disease
Antioxid. Redox Signal. 2020, 32, 1155-1171
Bapst A.M., Dahl S.L., Knöpfel T., Wenger R.H.
Cre-mediated, loxP independent sequential recombination of a tripartite transcriptional stop cassette allows for partial read-through transcription
Biochim. Biophys. Acta Gene Regul. Mech. 2020, 1863, 194568
Sulser P., Pickel C., Günter J., Leissing T.M., Crean D., Schofield C.J., Wenger R.H., Scholz C.C.
HIF hydroxylase inhibitors decrease cellular oxygen consumption depending on their selectivity
FASEB J. 2020, 34, 2344-2358
Pickel C., Günter J., Ruiz-Serrano A., Spielmann P., Fabrizio J.-A., Wolski W., Peet D.J., Wenger R.H., Scholz C.C.
Oxygen-dependent bond formation with FIH regulates the activity of the client protein OTUB1
Redox Biol. 2019, 26, 101265
Imeri F., Nolan K.A., Bapst A.M., Santambrogio S., Abreu Rodríguez I., Spielmann P., Pfundstein S., Libertini S., Crowther L., Orlando I.M.C., Dahl S.L., Keodara A., Kuo W., Kurtcuoglu V., Scholz C.C., Qi W., Hummler E., Hoogewijs D., Wenger R.H.
Generation of renal Epo-producing cell lines by conditional gene tagging reveals rapid HIF-2 driven Epo kinetics, cell autonomous feedback regulation and a telocyte phenotype.
Kidney Int. 2019, 95, 375-387
Orlando I.M.C., Lafleur V.N., Storti F., Spielmann P., Crowther L., Santambrogio S., Schödel J., Hoogewijs D., Mole D.R., Wenger R.H.
Distal and proximal hypoxia response elements cooperate to regulate organ-specific erythropoietin gene expression
Haematologica 2020: Vol 105 (12): 2774-2784; doi: 10.3324/haematol.2019.236406
Randi E.B., Benjamin V., Tsachaki M., Porto E., Vermeylen S., Lindenmeyer M.T., Le T.T.T., Cohen C.D., Devuyst O., Kistler A., Szabo C., Kawada N., Hankeln T., Odermatt A., Dewilde S., Wenger R.H., Hoogewijs D.
The anti-oxidative role of cytoglobin in podocytes suggests an association with chronic kidney disease
Antioxid. Redox Signal. 2020, 32:1155-1171
Bapst A.M., Dahl S.L., Knöpfel T., Wenger R.H. (2020)
Cre-mediated, loxP independent sequential recombination of a tripartite transcriptional stop cassette allows for partial read-through transcription
Biochim. Biophys. Acta Gene Regul. Mech. 2020, 1863:194568
Sulser P., Pickel C., Günter J., Leissing T.M., Crean D., Schofield C.J., Wenger R.H., Scholz C.C.
HIF hydroxylase inhibitors decrease cellular oxygen consumption depending on their selectivity
FASEB J. 2020, 34:2344-2358
Pickel C., Günter J., Ruiz-Serrano A., Spielmann P., Fabrizio J.-A., Wolski W., Peet D.J., Wenger R.H., Scholz C.C.
Oxygen-dependent bond formation with FIH regulates the activity of the client protein OTUB1
Redox Biol. 2019, 26:101265
Imeri F., Nolan K.A., Bapst A.M., Santambrogio S., Abreu-Rodriguez I., Spielmann P., Pfundstein S., Libertini S.,
Crowther L., Orlando I.M.C., Dahl S.L., Keodara A., Kuo W., Kurtcuoglu V., Scholz C.C., Weihong Q., Hummler E.,
Hoogewijs D., Wenger R.H.
Generation of renal Epo-producing cell lines by conditional gene tagging reveals rapid HIF-2 driven Epo kinetics,
cell autonomous feedback regulation, and a telocyte phenotype
Kidney Int 2019, 95: 375-387
Pickel C., Taylor CT., Scholz C.
Genetic Knockdown and Pharmacologic Inhibition of Hypoxia-Inducible Factor (HIF) Hydroxylases
Methods Mol Biol 2018, 1742: 1-14
Cosin-Roger J., Simmen S., Melhem H., Atrott K., Frey-Wagner I., Hausmann M., de Vallière Ch., Spalinger M.R.,
Spielmann P., Wenger R.H., Zeitz J., Vavricka S. R., Rogler G., Ruiz P.A.
Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation
Nat Commun 2017, 8:98
Günter J., Ruiz-Serrano A., Pickel C., Wenger RH., Scholz CC.
The functional interplay between the HIF pathway and the ubiquitin system - more than a one-way road
Exp Cell Res 2017, 356 (2): 152-159
Gutsche K., Randi E.B., Blank V., Fink D., Wenger R.H., Leo C., Scholz C.C.
Intermittent hypoxia confers pro-metastatic gene expression selectively through NF-κB in inflammatory
breast cancer cells
Free Radical Biology and Medicine, 2016, 101, 129-142
Dahl S.L., Bapst A.M., Khodo S.N., Scholz C.C., Wenger R.H.
Fount, fate, features and function of renal erythropoietin-producing cells.
Pflügers Arch. (Eur. J. Physiol.) 2022, 474, 783-797
Volkova Y.L., Pickel C., Jucht A. E., Wegner R.H., Scholz C.C.
The Asparagine hydroxylase FIH: a unique oxygen sensor.
Antioxid Redox Signal 2022,37, 913-935
Wenger R.H.
Thin Air-thick science
Nat. Rev. Mol. Cell Biol. 2020, 21 567
Fandrey J., Schödel J., Eckardt. K.U., Katschinski D.M., Wenger R.H.
Now a Nobel gas: oxygen
Pflügers Arch. (Eur. J. Physiol.) 2019, 471: 1343-1358
Nolan K.A., Wenger R.H.
Source and microenvironmental regulation of erythropoietin in the kidney
Curr. Opin. Nephrol. Hypertens. 2018, 27: 277-282
Günter J., Ruiz-Serrano A., Pickel C., Wenger R.H., Scholz C.C.
The functional interplay between the HIF pathway and the ubiquitin system - more than a one-way road
Exp. Cell Res. 2017, 356:152-159
Wenger R.H., Kurtcuoglu V., Scholz C.C., Marti H.H., Hoogewijs D.
Frequently asked questions in hypoxia research
Hypoxia 2015, 3: 35-43
