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Institute of Physiology

Relevant publications


Most relevant publications of the last few years

Papers

For full list of publications, please see (link zu pubmed):
https://www.ncbi.nlm.nih.gov/myncbi/1-Wqf20FYmEAQ/bibliography/public/

2019

Amar A, Majmundar AJ, Ullah I, Afzal A, Braun DA, Shril S, Daga A, Jobst-Schwan T, Ahmad M, Sayer JA, Gee HY, Halbritter J, Knoepfel T, Hernando N, Werner A, Wagner C, Khaliq S, Hildebrandt F.
Gene panel sequencing identifies a monogenic cause in 7 % of 235 Pakistani families with nephrolithiasis.
Hum Genet. 2019 Mar;138(3):211-219, 2019

Egli-Spichtig D, Imenez Silva PH, Glaudemans B, Gehring N, Bettoni C, Zhang MYH, Pastor-Arroyo EM, Schönenberger D, Rajski M, Hoogewijs D, Knauf F, Misselwitz B, Frey-Wagner I, Rogler G, Ackermann D, Ponte B, Pruijm M, Leichtle A, Fiedler GM, Bochud M, Ballotta V, Hofmann S, Perwad F, Föller M, Lang F, Wenger RH, Frew I, Wagner CA.
Tumor necrosis factor stimulates fibroblast growth factor 23 levels in chronic kidney disease and non-renal inflammation.
Kidney Int. 2019

Knöpfel T, Himmerkus N, Günzel D, Bleich M, Hernando N, Wagner CA.
Paracellular transport of phosphate along the intestine.
Am J Physiol Gastrointest Liver Physiol, 2019

2018

Wiegand A, Ritter A, Graf N, Arampatzis S, Sidler D, Hadaya K, Müller TF, Wagner CA, Wüthrich RP, Mohebbi N.
Preservation of kidney function in kidney transplant recipients by alkali therapy (Preserve-Transplant Study): rationale and study protocol.
BMC Nephrol. 19: 177, 2018

Daryadel A, Bettoni C, Haider T, Imenez Silva PH, Schnitzbauer U, Pastor-Arroyo EM, Wenger RH, Gassmann M, Wagner CA.
Erythropoietin stimulates fibroblast growth factor 23 (FGF23) in mice and men.
Pflugers Arch. 470: 1569-1582, 2018

Pastor-Arroyo EM, Gehring N, Bettoni C, Knöpfel T, Sabrautzki S, Lorenz-Depiereux B, Strom TM, Hrabě de Angelis M, Wagner CA, Rubio-Aliaga I.
Primary high circulating FGF23 levels do not increase cardiovascular disease risk.
Kidney Int, 94: 49-59, 2018, (shared last authorship)

Enerbäck S, Nilsson D, Edwards N, Heglind M, Alkanderi S, Ashton E, Deeb A, Kokash FEB, Bakhsh ARA, van’t Hoff W, Walsh SB, D’Arco F, Daryadel A, Bourgeois S, Wagner CA*, Kleta R*, Bockenhauer D*, Sayer J*.
Acidosis and deafness in patients with recessive mutations in the forkhead transcription factor FOXI1.
J Amer Soc Nephrol, 29: 1041-1048, 2018, (*shared last authorship).

Wang Y, de Valliere C, Leonardi I, Gruber S, Gerstgrasser A, Melhem H, Weber A, Leucht K,  Wolfram L, Hausmann M, Krieg C, Thomasson K, Boyman O, Frey-Wagner I, Rogler G*, Wagner CA*.
The proton-activated receptor GPR4 modulates intestinal inflammation.
J Crohns Colitis, 12: 355-368, 2018, (*shared last authorship)

Bourgeois S, Bounoure L, Mouro-Chanteloup I, Colin Y, Brown D, Wagner CA.
The ammonia transporter RhCG modulates urinary acidification by interacting with vacuolar H+-ATPases in renal intercalated cells.
Kidney Int, 93: 390-402, 2018

King AJ, Siegel M, He Y, Nie B, Wang J, Koo-McCoy S, Minassian NA, Jafri Q, Pan D, Kohler J, Kumaraswamy P, Kozuka K, Lewis JG, Dragoli D, Rosenbaum DP, O'Neill D, Plain A, Greasley PJ, Jönsson-Rylander AC, Karlsson D, Behrendt M, Strömstedt M, Ryden-Bergsten T, Knöpfel T, Pastor Arroyo EM, Hernando N, Marks J, Donowitz M, Wagner CA, Alexander RT, Caldwell JS.
Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability.
Sci Transl Med. 29; 10 (456), 2018

2017

Knöpfel T, Pastor EM, Schnitzbauer U, Kratschmar D, Odermatt A, Hernando*, Wagner CA*.
The intestinal phosphate transporter NaPi-IIb (Slc34a2) is required to protect bone during dietary phosphate restriction.
Sci Rep. 7: 11018, 2017, (*shared last authorship)

Thomas L, Bettoni C, Knöpfel T, Hernando N, Biber J, Wagner CA.
Parathyroid hormone is critical for the acute adaption to oral or intravenous phosphate loading.
J Am Soc Nephrol, 28: 903-914, 2017

2016

Schlingmann KP, Ruminska J, Kaufmann M, Haisch L, Dursun I, Patti M,  Bettoni C, Kranz B, Pronicka E, Ciara E, Akcay T, Güran T, Bulus D, Cornelissen EAM, Monnens LA, Lameris AL, Gawlik A, Sikora P, Patzer L, Galiano M, Rascher W, Boyadzhiev V, Dumic M, Vivante A, Anikster Y, Kleta R, Dekel B, Levtchenko E, Hoenderop JG, Bindels RJ, Rust S, Stoll M, Forster IC, Hernando N, Jones G, Wagner CA, Konrad M.
Idiopathic Infantile Hypercalcemia and recessive mutations in SLC34A1 (NaPi-IIa).
J Am Soc Nephrol, 27: 604-14, 2016

Daryadel A, Bourgeois S, Figueiredo MFL, Gomes Moreira A, Kampik NB, Arnet L, Mohebbi N, Lu X,  Meima ME, Danser AHJ, Wagner CA.
Colocalization of the (Pro)renin receptor/Atp6ap2 with H+-ATPases in mouse kidney but prorenin does not acutely regulate intercalated cell H+-ATPase activity.
PlosOne, 11(1): e0147831, 2016

Chan K, Busque, SM, Sailer M, Stoeger C, Bröer S, Daniel H, Rubio-Aliaga I, Wagner CA.
Loss of function mutation of the Slc38a3 glutamine transporter reveals its critical role for amino acid metabolism in liver, brain, and kidney.
Pflügers Arch, 468: 213-27, 2016

Dinour D, Davidovits M, Ganon L, Ruminska J, Forster IC, Hernando N, Eyal E, Holtzman EJ, Wagner CA.
Loss of function of NaPiIIa causes nephrocalcinosis and possibly kidney insufficiency.
Pediatr Nephrol. 31: 2289-229, 2016

2015

Maria J. van den Wildenberg MJ, Hoorn EJ,  Mohebbi N , Wagner CA, Woittiez AJ, de Vries PAM, Laverman GD.
Distal renal tubular acidosis with multi-organ autoimmunity.
Am J Kid Dis, 65: 607-10, 2015

Kumar NN, Velic A, Soliz J, Shi Y, Li K, Wang S, Weaver JL, Sen J, Abbott SBG, Lazarenko RM, Ludwig MG, Perez-Reyes E, Mohebbi N, Bettoni C, Gassmann M, Suply T, Seuwen K, Guyenet PG, Wagner CA*, Bayliss DA*.
Regulation of breathing by CO2/H+ requires selective expression of the proton-activated receptor, GPR4, in retrotrapezoid nucleus neurons.
Science, 348: 1255-60, 2015, (*shared last authorship)

Hernando N, Myakala K, Simona F, Knöpfel T, Thomas L, Murer H, Wagner CA, Biber J.
Intestinal depletion of NaPi-IIb/Slc34a2 in mice: renal and hormonal adaptation.
J Bone Min Res., 30: 1925-37, 2015

Bürki R, Mohebbi N, Bettoni C, Wang X, Serra AL, Wagner CA.
Impaired ammoniagenesis underlies renal acidosis in a rat model of chronic kidney disease.
Nephrol Dial Transplant, 30: 770-81, 2015

Todkar A, Picard N, Loffing-Cueni D,  Sorensen MV, Mihailova M, Nesterov V, Makhanova N, Smithies O, Korbmacher C, Wagner CA*, Loffing J*.
Maintained renal but impaired colonic control of potassium homeostasis in aldosterone deficient mice.
J Am Soc Nephrol, 26: 425-38, 2015, (*shared last authorship)

2014

Myakala K, Murer H, Wagner CA, Koesters R, Biber J, Hernando N.
Renal-specific and inducible depletion of NaPi-IIc/Slc34A3, the cotransporter mutated in HHRH, does not affect phosphate or calcium homeostasis in mice.
Am J Physiol Renal Physiol, 306: F833-43, 2014

Bounoure L, Ruffoni D, Müller R, Kuhn GA, Devuyst O, Bourgeois S, Wagner CA.
The elimination of an acidogenic high protein diet by the kidney depends on the ammonia transporter Rhcg and impacts on bone.
J Am Soc Nephrol, 25: 2040-52, 2014

Spichtig D, Zhang H, Mohebbi N, Pavik I, Petzold K, Stange G, Saleh L, Biber J,  Jaeger P, Serra AL*, Wagner CA*.
Renal Expression of FGF23 and Peripheral Resistance to elevated FGF23 in Rodent Models of Polycystic.
Kidney Disease. Kidney Int, 85: 1340-50, 2014, (*shared last authorship)

2013

Giudici L, Velic A, Daryadel A, Bettoni C, Mohebbi N, Suply T, Seuwen K, Ludwig MG, Wagner CA.
The proton-activated receptor GPR4 modulates glucose homeostasis by increasing insulin sensitivity.
Cell Physiol Biochem, 32: 1403-16, 2013

Mohebbi N, Vargas-Poussou R, Hegemann S, Schuknecht B, Kistler A, Wüthrich R, Wagner C .
Homozygous and compound heterozygous mutations in the ATP6V1B1 gene in patients with renal tubular acidosis and sensorineural hearing loss.
Clin Genet. 83: 274-8, 2013

Bourgeois S, Bounoure L, Christensen EI, Ramakrishnan SK, Houillier P, Devuyst O, Wagner CA.
Haploinsufficiency of the ammonia transporter Rhcg predisposes to chronic acidosis. Rhcg is critical for apical and basolateral ammonia transport in the mouse collecting duct.
J Biol Chem. 288: 5518-29, 2013

Tokonami N, Morla L, Centeno G, Mordasini D, Ramakrishnan SK, Nikolaeva S, Wagner CA, Bonny O , Houillier P, Doucet A, Firsov D.
Alpha-ketoglutarate regulates acid-base balance through an intra-renal paracrine mechanism.
J Clin Invest 123: 3166-71, 2013

Stettner P, Bourgeois S, Marsching C, Traykova-Brauch M, Porubsky S, Nordström V, Hopf C, Kösters R, Sandhoff R, Wiegandt H, Wagner CA, Gröne HJ, Jennemann R.
Sulfatides are required for renal adaptation to chronic metabolic acidosis.
Proc Natl Acad Sci USA 110: 9998-10003, 2013

Bourgeois S, Capuano P, Stange G, Mühlemann R, Murer H, Biber J, Wagner CA.
The phosphate transporter NaPi-IIa determines the rapid renal adaptation to dietary phosphate intake in mouse irrespective of persistently high FGF23 levels.
Pflügers Arch 465: 1557-72, 2013

Di Giacopo A, Rubio-Aliaga I, Cantone A, Artunc F, Rexhepaj R, Frey-Wagner I, Font-Llitjós M, Gehring N, Stange G, Jaenecke I, Mohebbi N, Closs EI, Palacín M, Nunes V, Daniel H, Lang F, Capasso G, Wagner CA.
Differential cystine and dibasic amino acid handling after loss-of-function of the amino acid transporter b0,+AT (Slc7a9) in mice.
Am J Physiol Renal Physiol, 305: F1645-55, 2013

Pavik I, Jaeger P, Ebner L, Wagner CA, Petzold K, Spichtig D, Poster D, Wüthrich RP, Russmann S, Serra AL.
Secreted Klotho and FGF23 in chronic kidney disease stage 1 to 5: A sequence suggested from a cross-sectional study.
Nephrol Dial Transplant 28: 352-9, 2013

2012

Pavik I, Jaeger P, Ebner L, Poster D, Krauer F, Kistler AD, Rentsch K, Andreisek G, Wagner CA, Devuyst O, Wüthrich RP, Schmid C, Serra AL.
Soluble Klotho and autosomal dominant polycystic kidney disease.
Clin J Am Soc Nephrol. 7: 248-57, 2012

Mohebbi N, Benabbas C, Vidal S, Daryadel A, Bourgeois S, Velic A, Ludwig MG, Seuwen K, Wagner CA.
The proton-activated G protein coupled receptor OGR1 acutely regulates the activity of epithelial proton transport proteins.
Cell Physiol Biochem. 29: 313-24, 2012

Todkar A, Di Chiara M, Loffing-Cueni D, Bettoni C, Mohaupt M, Loffing J, Wagner CA.
Aldosterone deficiency adversely affects pregnancy outcome in mice.
Pflügers Arch 464: 331-43, 2012

2011

Winter C, Kampik NB, Vedovelli L, Rothenberger F, Paunescu TG, Stehberger PA, Brown D, John H, Wagner CA.
Aldosterone stimulates vacuolar H+-ATPase activity in renal acid-secretory intercalated cells mainly via a protein kinase C-dependent pathway.
Am J Physiol Cell Physiol. 301: C1251-61, 2011

Welsh-Bacic D, Nowik M, Kaissling B, Wagner CA.
Proliferation of acid-secretory cells in the kidney during adaptive remodelling of the collecting duct.
PLoS One. 6: e25240, 2011

Bhandaru M, Kempe DS, Rotte A, Capuano P, Pathare G, Sopjani M, Alesutan I, Tyan L, Huang DY, Siraskar B, Judenhofer MS, Stange G, Pichler BJ, Biber J, Quintanilla-Martinez L, Wagner CA, Pearce D, Föller M, Lang F.
Phosphaturia in gene-targeted mice lacking functional SGK3.
Kidney Int 80: 61-7, 2011

Föller M, Kempe DS, Boini KM, Pathare G, Siraskar B, Capuano P, Alesutan I, Sopjani M,  Stange G, Mohebbi N, Bhandaru M, Ackermann TF, Judenhofer MS, Pichler BJ, Biber J,  Wagner CA, Lang F.
Calciuria and phosphaturia in mice expressing PKB/SGK-resistant GSK3.
J Am Soc Nephrol 22: 873-80, 2011

2010

Becker HM, Mohebbi N, Perna A, Ganapathy V, Capasso G, Wagner CA.
Localization of members of MCT monocarboxylate transporter family Slc16 in the kidney and regulation during metabolic acidosis.
Am J Physiol Renal Physiol 299: F141-54, 2010.

Picard N, Capuano P, Stange G, Mihailova M, Kaissling B, Murer H, Biber J, Wagner CA.
Acute parathyroid hormone differentially regulates renal brush border membrane phosphate cotransporters.
Pflugers Arch. 460: 677-87, 2010

Nowik M, Kampik NB, Mihailova M, Eladari D, Wagner CA.
Induction of metabolic acidosis with ammonium chloride (NH4Cl) in mice and rats--species differences and technical considerations.
Cell Physiol Biochem 26: 1059-72, 2010

2009

Renkema KY, Velic A, Dijkman HB, Verkaart S, van der Kemp AW, Nowik M, Timmermans K, Doucet A, Wagner CA, Bindels RJ, Hoenderop JG.
The calcium-sensing receptor promotes urinary acidification to prevent nephrolithiasis.
J Am Soc Nephrol. 20: 1705-13, 2009

Busque SM, Wagner CA.
Potassium restriction, high protein intake, and metabolic acidosis increase expression of the glutamine transporter SNAT3 (Slc38a3) in mouse kidney.
Am J Physiol Renal Physiol. 297: F440-50, 2009

Mohebbi N, Mihailova M, Wagner CA.
The calcineurin inhibitor FK506 (tacrolimus) is associated with transient metabolic acidosis and altered expression of renal acid-base transport proteins.
Am J Physiol Renal Physiol. 297: F499-509, 2009

2008

Biver S*, Belge H*, Bourgeois S*, Van Vooren P, Nowik M, Scohy S, Houillier P, Szpirer J, Szpirer C, Wagner CA, Devuyst O, Marini AM.
Impaired Ammonium Excretion, Renal Tubular Acidosis and Decreased Male Fertility in Mice Lacking the Rhcg Rhesus Factor.
Nature, 456: 339-43, 2008 (* shared first authorship)

Nowik M, Picard N, Stange G, Capuano P, Tenenhouse HS, Biber J, Murer H, Wagner CA.
Renal phosphaturia during metabolic acidosis revisited: molecular mechanisms for decreased renal phosphate reabsorption.
Pflugers Arch. 457: 539-49, 2008

Hafner P, Grimaldi R, Capuano P, Capasso G, Wagner CA.
Pendrin in the mouse kidney is primarily regulated by Cl- excretion but also by systemic metabolic acidosis.
Am J Physiol Cell Physiol. 295: C1658-67, 2008

Nowik M, Lecca MR, Velic A, Rehrauer H, Brändli AW, Wagner CA.
Genome-wide gene expression profiling reveals renal genes regulated during metabolic acidosis.
Physiol Genomics, 32: 322-34, 2008

2007

Rothenberger F, Velic A, Stehberger PA, Kovacikova J, Wagner CA.
Angiotensin II stimulates vacuolar H+-ATPase activity in renal acid secretory intercalated cells from the outer medullary collecting duct.
J Am Soc Nephrol 18: 2085-93, 2007

Stehberger PA, Shmukler BE, Stuart-Tilley AK, Peters LL, Alper SL, Wagner CA.
Distal Renal Tubular Acidosis in Mice Lacking the AE1 (Band3) Cl-/HCO3- Exchanger (slc4a1).
J Am Soc Nephrol. 18: 1408-18, 2007

Mohebbi N, Kovacikova J, Nowik M, Wagner CA.
Thyroid hormone deficiency alters expression of acid-base transporters in rat kidney.
Am J Physiol Renal Physiol 293: F416-27, 2007

Moret C, Dave MH, Schulz N, Jiang JX, Verrey F, Wagner CA.
Regulation of renal amino acid transporters during metabolic acidosis.
Am J Physiol Renal Physiol. 292: F555-66, 2007

Remy C, Kirchhoff P, Hafner P, Busque SM, Müller MK, Geibel JP, Wagner CA.
Stimulatory pathways of the Calcium-Sensing Receptor on acid secretion in freshly isolated human gastric glands.
Cell Physiol Biochem 19: 33-42, 2007

2006

Danilczyk U, Sarao R, Remy C, Benabbas C, Stange G, Richter A, Arya S, Pospisilik JA, Camargo SMR, Makrides V, Ramadan T, Verrey F, Wagner CA, Penninger JM.
Essential role for collectrin in renal amino acid transport.
Nature 444: 1088-91, 2006

Kovacikova J, Winter C, Loffing-Cueni D, Loffing J, Finberg KE, Lifton RP, Hummler E, Rossier B, Wagner CA.
The connecting tubule is the main site of the furosemide induced urinary acidification by the vacuolar H+-ATPase.
Kidney Int. 70: 1706-16, 2006

Honegger KJ, Capuano P, Winter C, Bacic D, Stange G, Wagner CA, Biber J, Murer H, Hernando N.
Regulation of sodium-proton exchanger isoform 3 (NHE3) by PKA and exchange protein directly activated by cAMP (EPAC).
Proc Natl Acad Sci U S A. 103: 803-8, 2006

Bacic D, LeHir M, Biber J, Kaissling B, Murer H, Wagner CA.
The renal Na+/Phosphate cotransporter NaPi-IIa is internalized via the receptor-mediated endocytic route in response to parathyroid hormone.
Kidney Int. 69: 495-503, 2006

Kirchhoff P, Dave M H, Remy C, Kosiek O, Busque SM, Dufner M, Geibel JP, Verrey F, Wagner CA.
An amino acid transporter involved in gastric acid secretion.
Pflügers Arch. 451: 738-48, 2006

2005

Finberg KE, Wagner CA, Bailey MA, Paunescu TG, Breton S, Brown D, Giebisch G, Geibel JP, Lifton RP.
The B1-subunit of the H+ ATPase is required for maximal urinary acidification.
Proc. Natl. Acad. Sci. USA 102: 13616-13621, 2005

Radanovic T, Wagner CA, Murer H, Biber J.
Regulation of intestinal phosphate transport. I. Segmental expression and adaptation to low Pi-diet of the type IIb Na+/Pi-cotansporter in mouse small intestine.
Am J Physiol Gastro Liver, 288: G496-500, 2005

Stauber A, Radanovic T, Stange G, Murer H, Wagner CA*, Biber J*.
Regulation of intestinal phosphate transport: II. Metabolic acidosis stimulates Na+-dependent phosphate absorption and expression of the Na+/Pi-cotransporter NaPi-IIb in small intestine.
Am J Physiol Gastro Liver, 288: G501-6, 2005 (*shared last authorship)

Dufner MM, Kirchhoff P, Remy C, Hafner P, Muller MK, Cheng SX, Tang LQ, Hebert SC, Geibel JP, Wagner CA.
The Calcium-Sensing Receptor (CaSR) acts as a modulator of gastric acid secretion in freshly isolated human gastric glands.
Am J Physiol Gastrointest Liver Physiol. 289: G1084-90, 2005

2004

Winter C, Schulz N, Giebisch G, Geibel JP, Wagner CA.
Non-genomic stimulation of vacuolar H+-ATPases in intercalated renal tubule cells by aldosterone.
Proc. Natl. Acad. Sci. USA 101: 2636-41, 2004

Dave MH, Schulz N, Zecevic M, Wagner CA, Verrey F.
Expression of heteromeric amino acid transporters along the intestine.
J. Physiol. (London) 558: 597-610, 2004

Kleta R, Romeo E, Ristic Z, Ohura T, Stuart C, Arcos-Burgos M, Dave MH, Wagner CA, Camargo SRM, Inoue S, Matsuura N, Helip-Wooley A, Bockenhauer D, Warth R, Bernardini I, Viser G, Eggermann T, Lee P, Chairoungdua A, Jutabha P, Babu E, Nilwarangkoon S, Anzai N, Kanai Y, Verrey F, Gahl WA, Koizumi A.
Mutations in SLC6A19 (hBoAT1) are associated with the Hartnup disorder.
Nature Genet, 36: 999-1002, 2004

Pineda M*, Wagner CA*, Bröer A, Stehberger PA, Kaltenbach S, Gelpí JL, Martín del Río R, Zorzano A, Palacín M, Lang F, Bröer S.
The cystinuria-specific R365W mutation in the human rBAT subunit alters functional properties of the system b0,+ amino acid transporter.
Biochem. J. 377: 665-74, 2004 (*shared first authorship)

Bonnici B, Wagner CA.
Postnatal expression of transport proteins involved in acid-base transport in mouse kidney.
Pflügers Arch. 448:16-28, 2004

2003

Stehberger PA, Schulz N, Finberg KE, Karet FE, Giebisch G, Lifton RP, Geibel JP, Wagner CA.
Loclization and regulation of the ATP6V0A4 (a4) vacuolar H+-ATPase subunit defective in an inherited form of distal renal tubular acidosis.
J. Am. Soc. Nephrol. 14: 3027-3038, 2003

Bacic D, Schulz N, Biber J, Kaissling B, Murer H, Wagner CA.
Involvement of the MAPK-kinase pathway in the PTH mediated regulation of the proximal tubule type IIa Na+/Pi cotransporter in mouse kidney.
Pflügers Arch. 446: 52-60, 2003

Wagner CA, Lükewille U, Valles P, Breton S, Brown D, Giebisch GH, Geibel JP.
A rapid enzymatic method for the isolation of defined kidney tubule fragments from mouse.
Pflügers Arch 446: 623-32, 2003

2002

Wagner CA, Finberg KE, Stehberger PA, Lifton RP, Giebisch GH, Aronson PS, Geibel JP.
Regulation of the expression of the Cl-/anion exchanger pendrin in mouse kidney by acid-base status.
Kidney Int 62 : 2109-17, 2002

Egan ME, Glöckner-Pagel J, Ambrose CA, Cahill PA, Pappoe L, Balamuth N, Cho E, Canny S, Wagner CA, Geibel J, Caplan MJ.
Calcium-pump inhibitors induce functional surface expression of DeltaF508-CFTR protein in cystic fibrosis epithelial cells.

Nature Med. 8: 485-92, 2002

2001

Geibel JP, Wagner CA, Caroppo R, Qureshi I, Glöckner J, Manuelidis L, Kirchhoff P, Radebold K.
The stomach calcium sensing receptor (SCAR) is a modulator of gastric acid secretion.
J. Biol. Chem. 276: 39549-39552, 2001

Smith AN, Finberg KE, Wagner CA, Lifton RP, Devonald MA, Su Y, Karet FE.
Molecular cloning and characterization of Atp6n1b: a novel fourth murine vacuolar H+-ATPase a-subunit gene.
J. Biol. Chem. 276: 42382-42388, 2001

2000

Bröer A*, Wagner C*, Lang F, Bröer S.
Neutral amino acid transporter ASCT2 displays substrate induced Na+-exchange and a substrate gated anion-conductance.
Biochem. J. 346: 705-710, 2000 (*shared first authorship)

Wagner CA, Lükewille U, Kaltenbach S, Moschen I, Bröer A, Risler T, Bröer S, Lang F.
Functional and pharmacological characterization of the human Na+/carnitine cotransporter hOCTN2.
Am. J. Physiol.: Renal Physiol. 279: F584-F591, 2000

1999

Matskevitch J A*, Wagner CA*, Stegen C, Bröer S, Noll B, Risler T, Kwon HM, Handler JS, Busch AE, Lang F.
Functional characterization of the betaine/ GABA transporter BGT-1 expressed in Xenopus oocytes.
J. Biol. Chem. 274: 16709-16719, 1999 (* shared first authorship)

Grifa A, Wagner CA,  D'Ambrosio L, Melchionda S, Bernardi F, Lopez-Bigas N, Rabionet R,  Arbones M,  Monica MD,  Estivill X,  Zelante L, Lang F, Gasparini P.
Mutations in GJB6 cause nonsyndromic autosomal dominant deafness at DFNA3 locus.
Nature Genet. 23: 16-18, 1999

1998

Wagner CA, Giebisch G, Lang F, Geibel JP.
Angiotensin II stimulates vesicular H+-ATPase in rat proximal tubular cells.
Proc. Natl. Acad. Sci. USA 95, 9665-9668, 1998

Kohl B, Wagner CA, Huelseweh B, Busch AE, Werner A.
The Na+-phosphate cotransport system (NaPi-II) with a cleaved protein backbone: implications on function and membrane insertion.
J. Physiol. (London) 508: 341-350, 1998

1996

Wagner CA, Waldegger S, Osswald H, Biber J, Murer H, Busch AE,  Lang F.
Heavy metals inhibit Pi -induced currents through human brush border NaPi-3 cotransporter in Xenopus oocytes.
Am. J. Physiol. Renal Physiol 271: F926-F930, 1996

Chillarón J, Estevez R, Mora C, Wagner CA, Suessbrich H, Lang F, Gelpí JL, Testar X, Busch AE, Zorzano A, Palacín M.
Obligatory amino acid exchange via systems b0,+-like and y+L -like. A tertiary active transport mechanism for renal reabsorption of cystine and dibasic amino acids.
J. Biol. Chem. 271: 17761-17770, 1996

Busch AE, Schuster A, Waldegger S, Wagner CA, Zempel G, Bröer S, Biber J, Murer H, Lang F.
Expression of a renal type I sodium/phosphate -transporter (NaPi-1) induces a conductance in Xenopus oocytes permeable for organic and anorganic anions.
Proc. Natl. Acad. Sci. USA 93: 5347-5351, 1996

1995

Busch AE*, Wagner CA*, Schuster A, Waldegger S, Biber J, Murer H,  Lang F.
Properties of electrogenic Pi transport by a human renal brush border Na+/Pi transporter.
J. Am. Soc. Nephrol. 6: 1547-1551, 1995 (* shared first authorship)       

Reviews and Editorials

Viggiano D*, Wagner CA*, Blankestijn PJ, Bruchfeld A, Fliser D, Fouque D, Frische S, Gesualdo L, Gutiérrez E, Goumenos D, Hoorn EJ, Eckardt KU, Knauß S, König M, Malyszko J, Massy Z, Nitsch D, Pesce F, Rychlík I, Soler MJ, Spasovski G, Stevens KI, Trepiccione F, Wanner C, Więcek A, Zoccali C, Unwin R#, Capasso G#.
Minimal cognitive impairment and kidney disease: clinical aspects.
Nephrol Dial Transpl, 2019 (*shared first authorship, #shared last authorship)

Levi M, Gratton E, Forster IC, Hernando N, Wagner CA, Biber J, Sorribas V, Murer H.
Mechanisms of phosphate transport.
Nat Rev Nephrol, 2019

Wagner CA, Imenez Silva PH, Bourgeois S.
Molecular pathophysiology of acid-base disorders.
Sem Nephrol, 2019

Lederer E, Wagner CA.
Clinical aspects of the phosphate transporters NaPi-IIa and NaPi-IIb: mutations and disease associations.
Pflugers Arch. 471: 137-148, 2019

Wagner CA, Rubio-Aliaga I, Hernando N.
Renal phosphate handling and inherited disorders of phosphate reabsorption: an update.
Ped Nephrol, 34: 549-559, 2019

Hernando N, Wagner CA.
Mechanisms and regulation of intestinal phosphate absorption.
Compr Physiol. 8: 1065-1090, 2018

Mohebbi N, Wagner CA.
Pathophysiology, diagnosis and treatment of inherited distal renal tubular acidosis.
J Nephrol, 31: 511-522, 2018

Wagner, CA.
Is vitamin D3 bad for the kidney?
Nephrol Dial Transplant. 33: 2071-2072, 2018

Luft FC, Wagner CA.
Pendred, pendrin, pseudohypoaldosteronism type II, and renal tubular acidosis.
Kidney Int. 94: 457-459, 2018

Wagner CA, Silva PHI, Rubio-Aliaga I.
And the fat lady sings about phosphate and calcium.
Kidney Int 91: 270-72, 2017

Wagner CA.
Pendrin-A New Target for Diuretic Therapy?
J Am Soc Nephrol. 27: 3499-3501, 2016

Wagner CA, Mohebbi N, Bourgeois S.
The ugly duckling of urinary acidification: what is the contribution of the thick
ascending limb of the loop of Henle to urinary acidification?

Am J Physiol Renal Physiol., 309: F431-3, 2015

Wagner CA, Rubio-Aliaga I, Biber J, Hernando N.
Genetic diseases of renal phosphate handling.
Nephrol Dial Transplant, Suppl 4: iv45-54, 2014

Biber J, Murer H, Mohebbi N, Wagner CA.
Renal handling of phosphate and sulfate.
Compr Physiol. 4: 771-92. 2014

Wagner CA, Hernando N, Forster IC, Biber J.
The SLC34 family of sodium-dependent phosphate transporters.
Pflügers Arch. 466: 139-53, 2014

Wagner CA, Bourgeois S.
Two Rhesus protein ammonia tansporters team up to eliminate ammonium into urine
Am J Physiol Renal Physiol. 306: F721-3, 2014

Wagner CA.
The calcium-sensing receptor directly regulates proximal tubular functions.
Kidney Int. 84: 228-30, 2013

Christensen EI, Wagner CA, Kaissling B.
The urineferous tubule: structure and functional organization.
Compr Physiol. 2: 805-61, 2012

Brown D, Wagner CA.
Molecular mechanisms of Acid-base sensing by the kidney.
J Am Soc Nephrol. 23: 774-80, 2012

Wagner CA, Devuyst O, Belge H, Bourgeois S, Houillier P.
The rhesus protein RhCG: a new perspective in ammonium transport and distal urinary acidification.
Kidney Int. 79: 154-61, 2011

Wagner CA, Mohebbi N, Capasso G, Geibel JP.
The anion exchanger pendrin (SLC26A4) and renal acid-base homeostasis.
Cell Physiol Biochem. 28: 497-504, 2011

Wagner CA, Devuyst O, Bourgeois S, Mohebbi N.
Regulated acid-base transport in the collecting duct.
Pflugers Arch. 458: 137-56, 2009

Wagner CA, Biber J, Murer H.
Of Men and Mice: Who Is in Control of Renal Phosphate Reabsorption?
J Am Soc Nephrol. 19: 1625-6, 2008

Wagner CA
When proton pumps go sour: Urinary acidification and kidney stones.
Kidney Int. 73: 1103-5, 2008

Hernando N, Wagner C, Biber J, Murer H.
Kidney kinase network regulates renal ion cotransport.
J Clin Invest. 117: 3179-82, 2007

Wagner CA.
The emerging role of pendrin in renal chloride reabsorption.
Am J Physiol. Renal Physiol.  292: F912-3, 2007

Wagner CA, Biber J, Murer H.
What goes in must come out--the small intestine modulates renal phosphate excretion.
Nephrol Dial Transplant. 22: 3411-2, 2007

Wagner CA, Finberg KE, Breton S, Marshansky V, Brown D, Geibel J P.
Renal vacuolar H+-ATPases.
Physiol. Rev. 84: 1263-314, 2004

Wagner CA, Lang F, Bröer S.
Function and structure of heterodimeric amino acid transporters.
Am. J. Physiol. Cell Physiol. 281, C1077-1093, 2001

Books and Book Chapters

 

Murer H, Biber J, Wagner CA.
Phosphate homeostasis.
Oxford Textbook of Clinical Nephrology, 4th edition, 2015

Wagner CA, Devuyst O.
Renal acid-base homeostasis.
Oxford Textbook of Clinical Nephrology, 4th edition, 2015

Wagner CA, Hernando N, Biber J, Murer H.
Genetic defects in renal phosphate handling.
Genetic diseases of the kidney. 2nd edition, Lifton RP, Somlo S, Giebisch G, Seldin D. (eds). Elsevier, 2015

Wagner CA, Hernando N, Forster IC, Biber J, Murer H.
Genetic defects in renal phosphate handling. In: Genetic diseases of the kidney.
1st edition, Lifton RP, Somlo S, Giebisch G, Seldin D. (eds). Elsevier, 2009

Wagner CA and Geibel JP.
Expression, function, and regulation of the H+/K+-ATPase in the kidney.
The Kidney. Alpern, R, Hebert, SC, Seldin, D, Giebisch, G. (eds). 4th edition, Lippincott 1269-1276, 2008

Bröer S, Wagner CA (eds).
Membrane transporter diseases.
Kluwer Academic/ Plenum Publishers: New York, 390 pp, 2004

 

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